Back to Search Start Over

Validation of Quantitative Flow Ratio-Derived Virtual Angioplasty with Post-Angioplasty Fractional Flow Reserve—The QIMERA-I Study

Authors :
Ignacio J. Amat-Santos
Giorgio Marengo
Juan Pablo Sánchez-Luna
Carlos Cortés Villar
Fernando Rivero Crespo
Víctor Alfonso Jiménez Díaz
José María de la Torre Hernández
Armando Pérez de Prado
Manel Sabaté
Ramón López-Palop
José Miguel Vegas Valle
Javier Suárez de Lezo
Clara Fernandez Cordon
Jose Carlos Gonzalez
Mario García-Gómez
Alfredo Redondo
Manuel Carrasco Moraleja
J. Alberto San Román
Source :
Journal of Cardiovascular Development and Disease, Vol 11, Iss 1, p 14 (2023)
Publication Year :
2023
Publisher :
MDPI AG, 2023.

Abstract

Background: Quantitative flow ratio (QFR) virtual angioplasty with pre-PCI residual QFR showed better results compared with an angiographic approach to assess post-PCI functional results. However, correlation with pre-PCI residual QFR and post-PCI fractional flow reserve (FFR) is lacking. Methods: A multicenter prospective study including consecutive patients with angiographically 50–90% coronary lesions and positive QFR results. All patients were evaluated with QFR, hyperemic and non-hyperemic pressure ratios (NHPR) before and after the index PCI. Pre-PCI residual QFR (virtual angioplasty) was calculated and compared with post-PCI fractional flow reserve (FFR), QFR and NHPR. Results: A total of 84 patients with 92 treated coronary lesions were included, with a mean age of 65.5 ± 10.9 years and 59% of single vessel lesions being the left anterior descending artery in 69%. The mean vessel diameter was 2.82 ± 0.41 mm. Procedural success was achieved in all cases, with a mean number of implanted stents of 1.17 ± 0.46. The baseline QFR value was 0.69 ± 0.12 and baseline FFR and NHPR were 0.73 ± 0.08 and 0.82 ± 0.11, respectively. Mean post-PCI FFR increased to 0.87 ± 0.05 whereas residual QFR had been estimated as 0.95 ± 0.05, showing poor correlation with post-PCI FFR (0.163; 95% CI:0.078–0.386) and low diagnostic accuracy (30.9%, 95% CI:20–43%). Conclusions: In this analysis, the results of QFR-based virtual angioplasty did not seem to accurately correlate with post-PCI FFR.

Details

Language :
English
ISSN :
23083425
Volume :
11
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Journal of Cardiovascular Development and Disease
Publication Type :
Academic Journal
Accession number :
edsdoj.7ae1088d9f04494bbc42f5536a614a36
Document Type :
article
Full Text :
https://doi.org/10.3390/jcdd11010014