One-year follow-up of accelerated transepithelial corneal collagen cross-linking for progressive pediatric keratoconus

Abstract Background Keratoconus typically presents in the teenage years and is more advanced in younger patients when compared with adults. In the present study, we aimed to assess the safety and efficacy of accelerated transepithelial corneal collagen cross-linking (ATE-CXL) in children with progressive keratoconus. Methods In this retrospective consecutive study, 18 eyes were enrolled from 17 pediatric patients (15 boys and 2 girls) with a mean age of 14.44 ± 1.98 years. Manifest refraction, best-corrected visual acuity (BCVA), steepest meridian keratometry (K1), flattest meridian keratometry (K2), maximum keratometry (Kmax), thinnest corneal thickness (TCT), posterior central elevation (PCE), and posterior mean elevation (PME) were measured before and after ATE-CXL. The patients were followed-up at 1, 6, and 12 months. Repeated measures analysis of variance was used for statistical analysis. P 0.05). Conclusions ATE-CXL is a safe and effective treatment in pediatric progressive keratoconus patients. The long-term effects need further observation. Trial registration Retrospectively registered. Registration number: ChiCTR-OIC-16008181. Registered 29 March 2016.