Back to Search Start Over

Characterization of Human B Cell Hematological Malignancies Using Protein-Based Approaches

Authors :
Cristina Jiménez
Alba Garrote-de-Barros
Carlos López-Portugués
María Hernández-Sánchez
Paula Díez
Source :
International Journal of Molecular Sciences, Vol 25, Iss 9, p 4644 (2024)
Publication Year :
2024
Publisher :
MDPI AG, 2024.

Abstract

The maturation of B cells is a complex, multi-step process. During B cell differentiation, errors can occur, leading to the emergence of aberrant versions of B cells that, finally, constitute a malignant tumor. These B cell malignancies are classified into three main groups: leukemias, myelomas, and lymphomas, the latter being the most heterogeneous type. Since their discovery, multiple biological studies have been performed to characterize these diseases, aiming to define their specific features and determine potential biomarkers for diagnosis, stratification, and prognosis. The rise of advanced -omics approaches has significantly contributed to this end. Notably, proteomics strategies appear as promising tools to comprehensively profile the final molecular effector of these cells. In this narrative review, we first introduce the main B cell malignancies together with the most relevant proteomics approaches. Then, we describe the core studies conducted in the field and their main findings and, finally, we evaluate the advantages and drawbacks of flow cytometry, mass cytometry, and mass spectrometry for the profiling of human B cell disorders.

Details

Language :
English
ISSN :
14220067 and 16616596
Volume :
25
Issue :
9
Database :
Directory of Open Access Journals
Journal :
International Journal of Molecular Sciences
Publication Type :
Academic Journal
Accession number :
edsdoj.7b68fea5188041c68a578385d15a8e65
Document Type :
article
Full Text :
https://doi.org/10.3390/ijms25094644