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A Metabolomic Signature of Ischemic Stroke Showing Acute Oxidative and Energetic Stress

Authors :
Moustapha Djite
Juan Manuel Chao de la Barca
Cinzia Bocca
Ndiaga Matar Gaye
Néné Oumou Kesso Barry
Mame Ndoumbé Mbacke
Ousmane Cissé
Pape Matar Kandji
Ndèye Marème Thioune
Najah Fatou Coly-Gueye
El Hadji Malick Ndour
Fatou Gueye-Tall
Amadou Gallo Diop
Gilles Simard
Delphine Mirebeau-Prunier
Papa Madieye Gueye
Pascal Reynier
Source :
Antioxidants, Vol 13, Iss 1, p 60 (2023)
Publication Year :
2023
Publisher :
MDPI AG, 2023.

Abstract

Metabolomics is a powerful data-driven tool for in-depth biological phenotyping that could help identify the specific metabolic profile of cryptogenic strokes, for which no precise cause has been identified. We performed a targeted quantitative metabolomics study in West African patients who had recently suffered an ischemic stroke, which was either cryptogenic (n = 40) or had a clearly identified cause (n = 39), compared to a healthy control group (n = 40). Four hundred fifty-six metabolites were accurately measured. Multivariate analyses failed to reveal any metabolic profile discriminating between cryptogenic ischemic strokes and those with an identified cause but did show superimposable metabolic profiles in both groups, which were clearly distinct from those of healthy controls. The blood concentrations of 234 metabolites were significantly affected in stroke patients compared to controls after the Benjamini–Hochberg correction. Increased methionine sulfoxide and homocysteine concentrations, as well as an overall increase in saturation of fatty acids, were indicative of acute oxidative stress. This signature also showed alterations in energetic metabolism, cell membrane integrity, monocarbon metabolism, and neurotransmission, with reduced concentrations of several metabolites known to be neuroprotective. Overall, our results show that cryptogenic strokes are not pathophysiologically distinct from ischemic strokes of established origin, and that stroke leads to intense metabolic remodeling with marked oxidative and energetic stresses.

Details

Language :
English
ISSN :
20763921
Volume :
13
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Antioxidants
Publication Type :
Academic Journal
Accession number :
edsdoj.7b7df610254033b36d5b1a813a43c2
Document Type :
article
Full Text :
https://doi.org/10.3390/antiox13010060