Research progress on hypercoagulable state in patients with acromegaly

Acromegaly is associated with systemic complications due to excess serum growth hormone, including cardiovascular diseases, endocrine and metabolic diseases, bone diseases and respiratory diseases. In addition, abnormalities of haemostatic function in patients with acromegaly have been described by several studies recently, including the alterations in coagulation, anticoagulation, fibrinolytic system and platelet function, presenting a potential of hyper-coagulation. Significantly elevated fibrinogen levels, reduced levels of protein C and protein S, and enhanced platelet activity were observed in patients with acromegaly. Some of these abnormalities are reversible after treatment like surgery or medication.