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Genome-wide identification of DNA methylation QTLs in whole blood highlights pathways for cardiovascular disease

Authors :
Tianxiao Huan
Roby Joehanes
Ci Song
Fen Peng
Yichen Guo
Michael Mendelson
Chen Yao
Chunyu Liu
Jiantao Ma
Melissa Richard
Golareh Agha
Weihua Guan
Lynn M. Almli
Karen N. Conneely
Joshua Keefe
Shih-Jen Hwang
Andrew D. Johnson
Myriam Fornage
Liming Liang
Daniel Levy
Source :
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Publication Year :
2019
Publisher :
Nature Portfolio, 2019.

Abstract

Differentially methylated CpGs can inform on disease mechanisms and be useful as biomarkers. Here, the authors perform GWAS for DNA methylation in whole blood, cis- and trans-meQTL mapping, followed by Mendelian randomization analysis that links meQTLs with cardiovascular diseases.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
10
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.7bdd0cfeebb44d3cb05a48f945dae102
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-019-12228-z