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Interethnic analyses of blood pressure loci in populations of East Asian and European descent

Authors :
Fumihiko Takeuchi
Masato Akiyama
Nana Matoba
Tomohiro Katsuya
Masahiro Nakatochi
Yasuharu Tabara
Akira Narita
Woei-Yuh Saw
Sanghoon Moon
Cassandra N. Spracklen
Jin-Fang Chai
Young-Jin Kim
Liang Zhang
Chaolong Wang
Huaixing Li
Honglan Li
Jer-Yuarn Wu
Rajkumar Dorajoo
Jovia L. Nierenberg
Ya Xing Wang
Jing He
Derrick A. Bennett
Atsushi Takahashi
Yukihide Momozawa
Makoto Hirata
Koichi Matsuda
Hiromi Rakugi
Eitaro Nakashima
Masato Isono
Matsuyuki Shirota
Atsushi Hozawa
Sahoko Ichihara
Tatsuaki Matsubara
Ken Yamamoto
Katsuhiko Kohara
Michiya Igase
Sohee Han
Penny Gordon-Larsen
Wei Huang
Nanette R. Lee
Linda S. Adair
Mi Yeong Hwang
Juyoung Lee
Miao Li Chee
Charumathi Sabanayagam
Wanting Zhao
Jianjun Liu
Dermot F. Reilly
Liang Sun
Shaofeng Huo
Todd L. Edwards
Jirong Long
Li-Ching Chang
Chien-Hsiun Chen
Jian-Min Yuan
Woon-Puay Koh
Yechiel Friedlander
Tanika N. Kelly
Wen Bin Wei
Liang Xu
Hui Cai
Yong-Bing Xiang
Kuang Lin
Robert Clarke
Robin G. Walters
Iona Y. Millwood
Liming Li
John C. Chambers
Jaspal S. Kooner
Paul Elliott
Pim van der Harst
The International Genomics of Blood Pressure (iGEN-BP) Consortium
Zhengming Chen
Makoto Sasaki
Xiao-Ou Shu
Jost B. Jonas
Jiang He
Chew-Kiat Heng
Yuan-Tsong Chen
Wei Zheng
Xu Lin
Yik-Ying Teo
E-Shyong Tai
Ching-Yu Cheng
Tien Yin Wong
Xueling Sim
Karen L. Mohlke
Masayuki Yamamoto
Bong-Jo Kim
Tetsuro Miki
Toru Nabika
Mitsuhiro Yokota
Yoichiro Kamatani
Michiaki Kubo
Norihiro Kato
Source :
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Publication Year :
2018
Publisher :
Nature Portfolio, 2018.

Abstract

Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200 genetic loci associated with BP are known. Here, the authors perform discovery GWAS for BP in East Asians and meta-analysis in East Asians and Europeans and report ancestry-specific BP SNPs and selection signals.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
9
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.7c763ccbcec74bc6b4f1c9dd802eadad
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-018-07345-0