Evaluation of Serotonin and Hystamine Exchange in Women with Premature Birth in Different Terms of Gestation

In modern obstetrics and gynecology, the problem of preterm labor is considered one of the most urgent.A significant number of factors affects on the run of pregnancy and it`s result, it`s activity is realized through numerical metabolic interactions, where an important role is given to biogenic monoamines, in particular serotonin and histamine. The aim of the study - to study the features of serotonin and histamine exchange in women`s body with different periods of abortion by determining in the blood the content of biogenic amines level of excretion with daily urine of serotonin 5-oxyindoloacetic acid and activity in the blood serum of the enzyme inactivation of histamine - histaminase. Material and methods of research – there were examined 227 pregnant women, 190 of these had clinical signs of the threat of preterm delivery in the gestation period of 23-36 weeks in the form of premature and timely childbirth. Women with early premature pregnancy, which ended with childbirth in the period from 23 to 27 weeks have a depletion of the functional activity of the serotonergic system. In women with late onset of pregnancy, there is an increasing of the serotoninergic system`s functional state, is probably with inhibition purpose of excessive excitement of stress-implementing systems. In women with a physiological course of pregnancy indicating an increasing of the histamine-histamine system activity with signs of a balance between the synthesis of biogenic amine and its inactivation. In women with early onset of pregnancy the inferiority of the blood system "histamine-histamine" develops, which is confirmed by a significant increasing of biogenic monoamine and reduction in the activity of the enzyme inactivation. In women with onset of pregnancy, there is a probable increasing of the histamine concentration in the blood indicating some exhaustion of "histamine-histaminase" systems with predominance signs of biogenic amine synthesis over its inactivation. Revealed changes in the state of serotonin and histamine in pregnant women indicate the violation of the adaptation mechanisms and the promoting possibility of the preterm labor development.