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Mucosal host-microbe interactions associate with clinical phenotypes in inflammatory bowel disease

Authors :
Shixian Hu
Arno R. Bourgonje
Ranko Gacesa
Bernadien H. Jansen
Johannes R. Björk
Amber Bangma
Iwan J. Hidding
Hendrik M. van Dullemen
Marijn C. Visschedijk
Klaas Nico Faber
Gerard Dijkstra
Hermie J. M. Harmsen
Eleonora A. M. Festen
Arnau Vich Vila
Lieke M. Spekhorst
Rinse K. Weersma
Source :
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Publication Year :
2024
Publisher :
Nature Portfolio, 2024.

Abstract

Abstract Disrupted host-microbe interactions at the mucosal level are key to the pathophysiology of IBD. This study aimed to comprehensively examine crosstalk between mucosal gene expression and microbiota in patients with IBD. To study tissue-specific interactions, we perform transcriptomic (RNA-seq) and microbial (16S-rRNA-seq) profiling of 697 intestinal biopsies (645 derived from 335 patients with IBD and 52 from 16 non-IBD controls). Mucosal gene expression patterns in IBD are mainly determined by tissue location and inflammation, whereas the mucosal microbiota composition shows a high degree of individual specificity. Analysis of transcript-bacteria interactions identifies six distinct groups of inflammation-related pathways that are associated with intestinal microbiota (adjusted P

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
15
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.7d585f4cd17d4027b8c1cce58bfea380
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-024-45855-2