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High spatial resolution nanoslit SERS for single-molecule nucleobase sensing

Authors :
Chang Chen
Yi Li
Sarp Kerman
Pieter Neutens
Kherim Willems
Sven Cornelissen
Liesbet Lagae
Tim Stakenborg
Pol Van Dorpe
Source :
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Publication Year :
2018
Publisher :
Nature Portfolio, 2018.

Abstract

Direct and real-time identification of nucleobases in DNA strands is still limited by the sensitivity and spatial resolution of the established solid-state nanopore devices. Here, the authors use CMOS compatible, plasmonic nanoslits to locally enable SERS for identifying nucleobases, both individual and incorporated in DNA strands.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
9
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.7db9e4ba038b4686a141eb151a141996
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-018-04118-7