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Calming effect of traditional Chinese medicine cinnabar based on neurotransmitter content and metal elements concentration in PCPA-induced insomnia rats
- Source :
- Pharmacological Research - Modern Chinese Medicine, Vol 11, Iss , Pp 100431- (2024)
- Publication Year :
- 2024
- Publisher :
- Elsevier, 2024.
-
Abstract
- Introduction: Cinnabar is a commonly utilized mineral traditional Chinese medicine (TCM) in China. It has the functions of clearing the heart and calming the mind. However, there remains a dearth of pharmacological experiments on the metal elements of cinnabar on animal models. Therefore, this study aims to investigate the effects of cinnabar on neurotransmitter levels in p-chlorophenylalanine (PCPA) induced insomnia rats and the content of metal elements in plasma, heart, liver, spleen, lung and kidney of rats. Methods: Tissue hematoxylin and eosin (H&E) staining were used to assess the histological changes. The 5-HT and GABA in plasma and hypothalamus of rats were determined by enzyme-linked immunosorbent to evaluate the therapeutic effect. The content of metal elements in plasma, heart, liver, spleen, lung and kidney of rats was determined by ICP-MS. Results: After cured with cinnabar and its processed for fourteen days, the level of 5-HT in the plasma and hypothalamus increased (P
Details
- Language :
- English
- ISSN :
- 26671425
- Volume :
- 11
- Issue :
- 100431-
- Database :
- Directory of Open Access Journals
- Journal :
- Pharmacological Research - Modern Chinese Medicine
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.7e2b2131f5154c78b203329a7ff15aaa
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.prmcm.2024.100431