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Interleukin-25 Enhances Allergic Inflammation through p38MAPK and NF-κB Pathways in Mouse Models of Allergic Rhinitis
- Source :
- Iranian Journal of Allergy, Asthma and Immunology, Vol 13, Iss 6 (2014)
- Publication Year :
- 2014
- Publisher :
- Tehran University of Medical Sciences, 2014.
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Abstract
- Interleukin (IL)-25, a cytokine of IL-17 family, can activate p38 Mitogen-Activated Protein kinases(MAPK) and Nuclear Factor(NF)-κB pathways to propagate Th2 responses. The allergic rhinitis mouse model was established by stimulating BALB/c mouse with ovalbumin (OVA). Then we detected expression of IL-25 and downstream p38MAPK and NF-κB. The expression of IL-25, p38MAPK and NF-κB were detected in the OVA-induced allergic rhinitis mouse model. The allergic parameters, such as allergic symptoms, serum OVA-specific immunoglobulin E (IgE) levels and eosinophil infiltration in the nasal mucosa were compared between OVA group and control group. OVA-induced mice displayed significantly higher allergic responses compared with the saline control group. OVA induced mice demonstrated more allergic symptoms, higher serum OVA-specific IgE levels and eosinophil infiltrations. The increased expression of IL-25, p38MAPK and NF-κB immunoreactivity were detected in epidermal cells in the OVA group. The mRNA measurement of IL-25, p38MAPK and NF-κB showed the same result. IL-25 enhances the OVA-induced allergic rhinitis by activating p38MAPK and NF-κB pathways.
- Subjects :
- Allergic rhinitis
Interleukin-25
Mice
NF-kappa B
p38 Mitogen-Activated
Medicine
Subjects
Details
- Language :
- English
- ISSN :
- 17351502 and 17355249
- Volume :
- 13
- Issue :
- 6
- Database :
- Directory of Open Access Journals
- Journal :
- Iranian Journal of Allergy, Asthma and Immunology
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.7eb0cd6bdd641409847031e57f5832f
- Document Type :
- article