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Caveolin 1 Modulates Aldosterone‐Mediated Pathways of Glucose and Lipid Homeostasis
- Source :
- Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 5, Iss 10 (2016)
- Publication Year :
- 2016
- Publisher :
- Wiley, 2016.
-
Abstract
- BackgroundOveractivation of the aldosterone and mineralocorticoid receptor (MR) pathway is associated with hyperglycemia and dyslipidemia. Caveolin 1 (cav‐1) is involved in glucose/lipid homeostasis and may modulate MR signaling. We investigated the interplay between cav‐1 and aldosterone signaling in modulating insulin resistance and dyslipidemia in cav‐1–null mice and humans with a prevalent variant in the CAV1 gene. Methods and ResultsIn mouse studies, cav‐1 knockout mice exhibited higher levels of homeostatic model assessment of insulin resistance, cholesterol, and resistin and lower ratios of high‐ to low‐density lipoprotein (all P
Details
- Language :
- English
- ISSN :
- 20479980
- Volume :
- 5
- Issue :
- 10
- Database :
- Directory of Open Access Journals
- Journal :
- Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.7ed1ec70b2b4a6b8a2e50760751ff45
- Document Type :
- article
- Full Text :
- https://doi.org/10.1161/JAHA.116.003845