Back to Search Start Over

Identification of significant chromatin contacts from HiChIP data by FitHiChIP

Authors :
Sourya Bhattacharyya
Vivek Chandra
Pandurangan Vijayanand
Ferhat Ay
Source :
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Publication Year :
2019
Publisher :
Nature Portfolio, 2019.

Abstract

HiChIP/PLAC-seq assay is popular for profiling 3D genome interactions among regulatory elements at kilobase resolution. Here the authors describe FitHiChIP an empirical null-based, flexible computational method for statistical significance estimation and loop calling from HiChIP data.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
10
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.7ef2ca6ec45b488485c5ff25afb3492e
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-019-11950-y