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Improved Synthesis and Crystal Structure of Dalcetrapib
- Source :
- Crystals, Vol 2, Iss 4, Pp 1455-1459 (2012)
- Publication Year :
- 2012
- Publisher :
- MDPI AG, 2012.
-
Abstract
- An improved synthesis of the Cholesteryl Ester Transfer Protein inhibitor dalcetrapib is reported. The precursor disulfide was reduced (a) by Mg/MeOH or (b) by EtSH/DBU/THF. The resulting thiol was acylated (a) by a known procedure or (b) in a one-pot process. Impurities were removed (a) by dithiothreitol (DTT) or (b) by oxidation using H2O2. Dalcetrapib crystallized in space group P21/c.
- Subjects :
- CETP inhibitor
dalcetrapib
disulfide
thioester
Crystallography
QD901-999
Subjects
Details
- Language :
- English
- ISSN :
- 20734352
- Volume :
- 2
- Issue :
- 4
- Database :
- Directory of Open Access Journals
- Journal :
- Crystals
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.7f74716736f94875bd60c1153655d292
- Document Type :
- article
- Full Text :
- https://doi.org/10.3390/cryst2041455