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Prevalence of transmitted drug resistance among ART-naïve HIV-infected individuals, Beijing, 2015–2018
- Source :
- Journal of Global Antimicrobial Resistance, Vol 28, Iss , Pp 241-248 (2022)
- Publication Year :
- 2022
- Publisher :
- Elsevier, 2022.
-
Abstract
- Objectives: Transmitted drug resistance (TDR) is a critical ongoing public health challenge in HIV/AIDS therapy. We explore the prevalence of TDR, its patterns, its associated risk factors, and predicted drug sensitivity in Beijing between 2015 and 2018. Methods: Retrospective data on TDR from 3265 antiretroviral therapy (ART)-naïve patients were collected at Beijing Ditan Hospital from 1 August 2014 to 31 July 2018. TDR was defined according to the Stanford Drug Resistance Mutations Database. TDR prevalence, pattern, risk factors, and predicted drug sensitivity were analysed. Results: The overall prevalence of HIV-1 TDR was 6.68% (218 of 3265), including 0.77%, 3.64%, and 2.36% resistance to nucleoside reverse transcriptase inhibitors (NRTIs), non-NRTIs (NNRTIs), and protease inhibitors, respectively. The thymidine analogue mutations (TAMs) M41L/LM (4, 0.12%) and non-TAMs mutations M184V/MV/MI (8; 0.24%) were the primary NRTI-associated resistance mutations. K103N/KN (NNRTI associated) and M46L/I/IMV/IM/ML (protease inhibitor associated) were the other major resistance mutations. Patients 40–59 years old who had the CRF08_BC subtype were identified as having higher risk for drug resistance mutation. Conclusions: The prevalence of TDR among ART-naïve individuals with HIV-1 in Beijing was at a moderate level. Long-time and continuous surveillance of HIV TDR is necessary step in the therapy of ART-naive patients.
- Subjects :
- HIV-1
Transmitted drug resistance
Beijing
Mutation
NNRTIs
Microbiology
QR1-502
Subjects
Details
- Language :
- English
- ISSN :
- 22137165
- Volume :
- 28
- Issue :
- 241-248
- Database :
- Directory of Open Access Journals
- Journal :
- Journal of Global Antimicrobial Resistance
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.7f9aad53a57a4746a921db3241873487
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.jgar.2022.01.017