Back to Search Start Over

Clinical and molecular relevance of genetic variants in the non-coding transcriptome of patients with cytogenetically normal acute myeloid leukemia

Authors :
Dimitrios Papaioannou
Hatice G. Ozer
Deedra Nicolet
Amog P. Urs
Tobias Herold
Krzysztof Mrózek
Aarif M.N. Batcha
Klaus H. Metzeler
Ayse S. Yilmaz
Stefano Volinia
Marius Bill
Jessica Kohlschmidt
Maciej Pietrzak
Christopher J. Walker
Andrew J. Carroll
Jan Braess
Bayard L. Powell
Ann-Kathrin Eisfeld
Geoffrey L. Uy
Eunice S. Wang
Jonathan E. Kolitz
Richard M. Stone
Wolfgang Hiddemann
John C. Byrd
Clara D. Bloomfield
Ramiro Garzon
Source :
Haematologica, Vol 107, Iss 5 (2021)
Publication Year :
2021
Publisher :
Ferrata Storti Foundation, 2021.

Abstract

Expression levels of long non-coding RNA (lncRNA) have been shown to associate with clinical outcome of patients with cytogenetically normal acute myeloid leukemia (CN-AML). However, the frequency and clinical significance of genetic variants in the nucleotide sequences of lncRNA in AML patients is unknown. Herein, we analyzed total RNA sequencing data of 377 younger adults (aged

Details

Language :
English
ISSN :
03906078 and 15928721
Volume :
107
Issue :
5
Database :
Directory of Open Access Journals
Journal :
Haematologica
Publication Type :
Academic Journal
Accession number :
edsdoj.7f9bf447eead48ccb2195be68f8f7b08
Document Type :
article
Full Text :
https://doi.org/10.3324/haematol.2021.266643