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A sexually dimorphic pre-stressed translational signature in CA3 pyramidal neurons of BDNF Val66Met mice

Authors :
Jordan Marrocco
Gordon H. Petty
Mariel B. Ríos
Jason D. Gray
Joshua F. Kogan
Elizabeth M. Waters
Eric F. Schmidt
Francis S. Lee
Bruce S. McEwen
Source :
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Publication Year :
2017
Publisher :
Nature Portfolio, 2017.

Abstract

Animals’ response to acute stress is known to be influenced by sex and genetics. Here the authors performed RNA-seq on actively translated mRNAs in hippocampal CA3 neurons in mice, and document the effects of sex and genotype (i.e., BDNF Val66Met) on acute stress-induced gene expression.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
8
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.801b66d7a1be477d9f8b4a7aaf7b868e
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-017-01014-4