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Combining metabolomics and transcriptomics to reveal the potential medicinal value of rare species Glycyrrhiza squamulose

Authors :
Bin Ma
Siru Wang
Haonan Li
Qinyue Wang
Yaqi Hong
Yang-mei Bao
Hua Liu
Ming Li
Yucheng Zhao
Lan-ping Guo
Source :
Heliyon, Vol 10, Iss 10, Pp e30868- (2024)
Publication Year :
2024
Publisher :
Elsevier, 2024.

Abstract

Licorice is a well-known Chinese medicinal plant that is widely used to treat multiple diseases and process food; however, wild licorice is now facing depletion. Therefore, there is an urgent need to identify and protect licorice germplasm diversity. In this study, metabolomic and transcriptomic analyses were conducted to investigate the biodiversity and potential medicinal value of the rare wild Glycyrrhiza squamulose. A total of 182 differentially accumulated metabolites and 395 differentially expressed genes were identified by comparing Glycyrrhiza uralensis and Glycyrrhiza squamulose. The molecular weights of the chemical component of G. squamulose were comparable with those of G. uralensis, suggesting that G. squamulose may have medicinal value. Differentially accumulated metabolites (DAMs), mainly flavonoids such as kaempferol-3-O-galactoside, kaempferol-3-O-(6ʺmalonyl) glucoside, and hispidulin-7-O-glucoside, showed potential vitality in G. squamulose. Comparative transcriptomics with G. uralensis showed that among the 395 differentially expressed genes (DEGs), 69 were enriched in the isoflavonoid biosynthesis pathway. Multiomics analysis showed that the distinction in flavonoid biosynthesis between G. squamulose and G. uralensis was strongly associated with the expression levels of IF7GT and CYP93C. In addition to identifying similarities and differences between G. squamulose and G. uralensis, this study provides a theoretical basis to protect and investigate rare species such as G. squamulose.

Details

Language :
English
ISSN :
24058440
Volume :
10
Issue :
10
Database :
Directory of Open Access Journals
Journal :
Heliyon
Publication Type :
Academic Journal
Accession number :
edsdoj.8073138e18b4ced9d4896d742a83c82
Document Type :
article
Full Text :
https://doi.org/10.1016/j.heliyon.2024.e30868