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Transmissibility of MERS-CoV Infection in Closed Setting, Riyadh, Saudi Arabia, 2015
- Source :
- Emerging Infectious Diseases, Vol 25, Iss 10, Pp 1802-1809 (2019)
- Publication Year :
- 2019
- Publisher :
- Centers for Disease Control and Prevention, 2019.
-
Abstract
- To investigate a cluster of Middle East respiratory syndrome (MERS) cases in a women-only dormitory in Riyadh, Saudi Arabia, in October 2015, we collected epidemiologic information, nasopharyngeal/oropharyngeal swab samples, and blood samples from 828 residents during November 2015 and December 2015–January 2016. We found confirmed infection for 19 (8 by reverse transcription PCR and 11 by serologic testing). Infection attack rates varied (2.7%–32.3%) by dormitory building. No deaths occurred. Independent risk factors for infection were direct contact with a confirmed case-patient and sharing a room with a confirmed case-patient; a protective factor was having an air conditioner in the bedroom. For 9 women from whom a second serum sample was collected, antibodies remained detectable at titers >1:20 by pseudoparticle neutralization tests (n = 8) and 90% plaque-reduction neutralization tests (n = 2). In closed high-contact settings, MERS coronavirus was highly infectious and pathogenicity was relatively low.
Details
- Language :
- English
- ISSN :
- 10806040, 10806059, and 40468321
- Volume :
- 25
- Issue :
- 10
- Database :
- Directory of Open Access Journals
- Journal :
- Emerging Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.8076fb93d9d4046832130b7923cc16e
- Document Type :
- article
- Full Text :
- https://doi.org/10.3201/eid2510.190130