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Effect of Methylphenidate on Methadone-Induced Analagesia in Rat
- Source :
- مجله دانشکده پزشکی اصفهان, Vol 33, Iss 327, Pp 316-325 (2015)
- Publication Year :
- 2015
- Publisher :
- Isfahan University of Medical Sciences, 2015.
-
Abstract
- Background: A known problem of chronic administration of opioid is tolerance to its analgesic effect. Co-administration of a non-opioid analgesic may help reducing the opiate dose and consequently tolerance and dependency. It is reported that repeated use of methylphenidate, one of amphetamines, increased the expression of µ opioid receptor and had antinociception. Therefore, this study aimed to evaluate the effect of methylphenidate on methadone-induced analgesia. Methods: Nine groups of 8 male rats weighting 270 ± 20 g were randomly selected; control group received 1 ml/kg oral normal saline, metylphenidate groups received 5, 10 and 15 mg/kg oral metylphenidate, methadone groups received 5, 10, 20 mg/kg oral methadone, and combined groups received 5 mg/kg methadone +5 or 15 mg/kg methylphenidate orally. Pain was measured using plantar test apparatus. Findings: Only, 15 mg/kg methylphenidate produced significant analgesic effect. In addition, co-administration of non-effective doses of methylphenidate and 5 mg/ kg methadone significantly increased the analgesic effects of methadone at 60 minutes after gavage. Conclusion: We found that methylphenidate potentiate the analgesic effects of methadone in rats.
- Subjects :
- Pain
Methadone
Methylphenidate
Plantar test
Medicine
Medicine (General)
R5-920
Subjects
Details
- Language :
- Persian
- ISSN :
- 10277595 and 1735854X
- Volume :
- 33
- Issue :
- 327
- Database :
- Directory of Open Access Journals
- Journal :
- مجله دانشکده پزشکی اصفهان
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.807f6efcb13e4c27b2c7e434513f2258
- Document Type :
- article