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VPS35, the core component of the retromer complex, and Parkinson's disease

Authors :
Ai‐Di Luo
Zu‐Cai Xu
Shu‐Sheng Liao
Source :
Ibrain, Vol 7, Iss 4, Pp 318-324 (2021)
Publication Year :
2021
Publisher :
Wiley-VCH, 2021.

Abstract

Abstract Parkinson's disease (PD) is a neurodegenerative disease that is common in middle‐aged and elderly people, and its onset is related to multiple factors, such as heredity, environment, and age. The vesicle protein sorting 35 (VPS35) gene was found to be a late‐onset autosomal dominant familial PD (PARK17) causative gene. The protein encoded by this gene is located in the endosome and aggregates with other membrane proteins to form a retromer complex, which participates in the membrane protein cycle between the endosome and the Golgi network. Increasing evidence shows that VPS35 may participate in the pathogenesis of PD by affecting autophagy, mitochondria, neurosynaptic transmission, dopamine signaling pathways, and so forth, and it can interact with other disease‐causing genes of familial PD. This article aimed to review the functions of VPS35 and the mechanism of its mutations in PD that have been discovered in recent years.

Details

Language :
English
ISSN :
27692795
Volume :
7
Issue :
4
Database :
Directory of Open Access Journals
Journal :
Ibrain
Publication Type :
Academic Journal
Accession number :
edsdoj.80ac89df0d7f4d2a83398c5ff301927d
Document Type :
article
Full Text :
https://doi.org/10.1002/ibra.12004