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The role of extracellular vesicles in the development of nasopharyngeal carcinoma and potential clinical applications
- Source :
- Cancer Medicine, Vol 12, Iss 13, Pp 14484-14497 (2023)
- Publication Year :
- 2023
- Publisher :
- Wiley, 2023.
-
Abstract
- Abstract Background Extracellular vesicles (EVs) can be secreted by a wide variety of cells, including tumor cells, and contain some bioactive molecules from the source cells. Therefore, they can potentially be used as biomarkers for early diagnosis of tumors and for tumor therapy. In addition, EVs can affect the features of target cells and participate in regulating the development process of tumors. Methods A literature review was conducted to elucidate the role of extracellular vesicles in the progression and treatment of nasopharyngeal carcinoma. Results In this review, we discuss the molecular mechanisms of cell proliferation, angiogenesis, epithelialâmesenchymal transformation and metastasis, immune response, and chemoâradiotherapy resistance that are induced by EVs. We also reviewed the potential applications of EVs as biomarkers, therapeutic agents, and carriers so as to determine new directions for the early diagnosis and targeted therapy of nasopharyngeal carcinoma. The application limitations have also been discussed in this review, further work is needed to ensure optimal outcomes for patients. Conclusion Although the roles of extracellular vesicles in the progression of nasopharyngeal carcinoma have been summarized, some aspects are still unclear and need to be further studied. In addition, the applications of extracellular vesicles in the treatment of nasopharyngeal carcinoma still need to optimize conditions to produce better therapeutic outcomes for patients with nasopharyngeal carcinoma.
Details
- Language :
- English
- ISSN :
- 20457634
- Volume :
- 12
- Issue :
- 13
- Database :
- Directory of Open Access Journals
- Journal :
- Cancer Medicine
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.80bc32d21028499f978a873ce328972f
- Document Type :
- article
- Full Text :
- https://doi.org/10.1002/cam4.6099