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Dual Role of WISP1 in maintaining glioma stem cells and tumor-supportive macrophages in glioblastoma

Authors :
Weiwei Tao
Chengwei Chu
Wenchao Zhou
Zhi Huang
Kui Zhai
Xiaoguang Fang
Qian Huang
Aili Zhang
Xiuxing Wang
Xingjiang Yu
Haidong Huang
Qiulian Wu
Andrew E. Sloan
Jennifer S. Yu
Xiaoxia Li
George R. Stark
Jeremy N. Rich
Shideng Bao
Source :
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Publication Year :
2020
Publisher :
Nature Portfolio, 2020.

Abstract

The tumour microenvironment plays an important role in promoting glioblastoma. Here, the authors show that glioma stem cells secrete WISP1, which promotes both the survival of the stem cells and tumour-associated macrophages.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
11
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.80ed06b6daa44b72a61177b8c8e47066
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-020-16827-z