DNA nicks induce mutational signatures associated with BRCA1 deficiency

Authors :: Yi-Li Feng
Qian Liu
Ruo-Dan Chen
Si-Cheng Liu
Zhi-Cheng Huang
Kun-Ming Liu
Xiao-Ying Yang
An-Yong Xie
Source :: Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Publication Year :: 2022
Publisher :: Nature Portfolio, 2022.
Abstract: It remains unclear how BRCA1-associated mutational sigantures are generated in cancer. Here, the authors develop nCas9-based approaches to uncover that aberrant repair of one-ended DSBs converted from DNA nicks by replication, not that of two-ended DSBs, induces such mutational signatures.

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