Back to Search
Start Over
Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria
- Source :
- Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
- Publication Year :
- 2019
- Publisher :
- Nature Portfolio, 2019.
-
Abstract
- Urinary albumin-to-creatinine ratio (UCAR) is associated with various clinical outcomes such as kidney disease and cardiovascular disease. Here, the authors report genome-wide meta-analysis in over 500,000 individuals and find 68 UACR loci, followed by statistical fine-mapping, gene prioritization and experimental validation in flies.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 10
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.811b967d47ba4a39939f7d7acdc91764
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-019-11576-0