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A four-protein metabolon assembled by a small peptide protein creates the pentacyclic carbonate ring of aldgamycins

Authors :
Qiaozhen Wang
Xiaolong Tang
Ping Dai
Chuanxi Wang
Weiyang Zhang
Guodong Chen
Kui Hong
Dan Hu
Hao Gao
Xinsheng Yao
Source :
Acta Pharmaceutica Sinica B, Vol 11, Iss 2, Pp 588-597 (2021)
Publication Year :
2021
Publisher :
Elsevier, 2021.

Abstract

Organic carbonates (OCs) are a class of compounds featured by a carbonyl flanked by two alkoxy/aryloxy groups. They exist in either linear or cyclic forms, of which the majority encountered in nature adopt a pentacyclic structure. However, the enzymatic basis for pentacyclic carbonate ring formation remains elusive. Here, we reported that a four-protein metabolon (AlmUIIā€“UV) assembled by a small peptide protein (AlmUV) appends a reactive N-hydroxylcarbamoyl moiety to the decarboxylated aldgamycins followed by a non-enzymatic condensation to give the pentacyclic carbonate ring. Our results have documented an unprecedent mechanism for carbonate formation.

Details

Language :
English
ISSN :
22113835
Volume :
11
Issue :
2
Database :
Directory of Open Access Journals
Journal :
Acta Pharmaceutica Sinica B
Publication Type :
Academic Journal
Accession number :
edsdoj.827fac6d3347dabb91cfa4f89e9dcc
Document Type :
article
Full Text :
https://doi.org/10.1016/j.apsb.2020.07.015