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The Impact of the CB2 Cannabinoid Receptor in Inflammatory Diseases: An Update

Authors :
Volatiana Rakotoarivelo
Thomas Z. Mayer
Mélissa Simard
Nicolas Flamand
Vincenzo Di Marzo
Source :
Molecules, Vol 29, Iss 14, p 3381 (2024)
Publication Year :
2024
Publisher :
MDPI AG, 2024.

Abstract

The emergence of inflammatory diseases is a heavy burden on modern societies. Cannabis has been used for several millennia to treat inflammatory disorders such as rheumatism or gout. Since the characterization of cannabinoid receptors, CB1 and CB2, the potential of cannabinoid pharmacotherapy in inflammatory conditions has received great interest. Several studies have identified the importance of these receptors in immune cell migration and in the production of inflammatory mediators. As the presence of the CB2 receptor was documented to be more predominant in immune cells, several pharmacological agonists and antagonists have been designed to treat inflammation. To better define the potential of the CB2 receptor, three online databases, PubMed, Google Scholar and clinicaltrial.gov, were searched without language restriction. The full texts of articles presenting data on the endocannabinoid system, the CB2 receptor and its role in modulating inflammation in vitro, in animal models and in the context of clinical trials were reviewed. Finally, we discuss the clinical potential of the latest cannabinoid-based therapies in inflammatory diseases.

Details

Language :
English
ISSN :
29143381 and 14203049
Volume :
29
Issue :
14
Database :
Directory of Open Access Journals
Journal :
Molecules
Publication Type :
Academic Journal
Accession number :
edsdoj.82da4078f2f94104b253783deeb35685
Document Type :
article
Full Text :
https://doi.org/10.3390/molecules29143381