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A mouse model reproducing the pathophysiology of neonatal group B streptococcal infection

Authors :
Elva Bonifácio Andrade
Ana Magalhães
Ana Puga
Madalena Costa
Joana Bravo
Camila Cabral Portugal
Adília Ribeiro
Margarida Correia-Neves
Augusto Faustino
Arnaud Firon
Patrick Trieu-Cuot
Teresa Summavielle
Paula Ferreira
Source :
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Publication Year :
2018
Publisher :
Nature Portfolio, 2018.

Abstract

Animal models of group-B streptococcal infections are needed to develop effective therapies. Here, Andrade et al. present a mouse model in which the bacteria are transmitted from vaginally colonised pregnant females to their offspring, causing neonatal meningitis and neurological developmental disabilities.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
9
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.8386576c08064b7cbf1996e40b3f601a
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-018-05492-y