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Targetable vulnerabilities in T- and NK-cell lymphomas identified through preclinical models

Authors :
Samuel Y. Ng
Noriaki Yoshida
Amanda L. Christie
Mahmoud Ghandi
Neekesh V. Dharia
Joshua Dempster
Mark Murakami
Kay Shigemori
Sara N. Morrow
Alexandria Van Scoyk
Nicolas A. Cordero
Kristen E. Stevenson
Maneka Puligandla
Brian Haas
Christopher Lo
Robin Meyers
Galen Gao
Andrew Cherniack
Abner Louissaint
Valentina Nardi
Aaron R. Thorner
Henry Long
Xintao Qiu
Elizabeth A. Morgan
David M. Dorfman
Danilo Fiore
Julie Jang
Alan L. Epstein
Ahmet Dogan
Yanming Zhang
Steven M. Horwitz
Eric D. Jacobsen
Solimar Santiago
Jian-Guo Ren
Vincent Guerlavais
D. Allen Annis
Manuel Aivado
Mansoor N. Saleh
Amitkumar Mehta
Aviad Tsherniak
David Root
Francisca Vazquez
William C. Hahn
Giorgio Inghirami
Jon C. Aster
David M. Weinstock
Raphael Koch
Source :
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Publication Year :
2018
Publisher :
Nature Portfolio, 2018.

Abstract

T- and NK-cell lymphomas (TCL) are a group of lymphoid malignancies characterized by poor prognosis, but the absence of appropriate pre-clinical models has hampered the development of effective therapies. Here the authors establish several pre-clinical models and identify vulnerabilities that could be further exploited to treat patients afflicted by these diseases.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
9
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.83cf960564bd2938fc055d45d8a01
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-018-04356-9