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Comparison of accelerated and enzyme-associated real-time degradation of HMW PLLA and HMW P3HB films
- Source :
- Polymer Testing, Vol 107, Iss , Pp 107471- (2022)
- Publication Year :
- 2022
- Publisher :
- Elsevier, 2022.
-
Abstract
- Designing laboratory-scale degradation experiments for polymer-based biomaterials is crucial for the development of safe and functional implants, in particular regarding high molecular weight polyesters. Within this work, we compared accelerated degradation of solvent cast HMW-PLLA and HMW-P3HB films at 55 °C (16 weeks) with enzyme-associated (proteinase K and lipases) real-time degradation at 37 °C (108 weeks). During real-time degradation, PLLA showed mass loss up to 83%, in contrast to accelerated conditions, where no changes occurred. Moreover, we observed wave-shape development of crystallinity for PLLA and PHB for both degradation conditions applied, whereby PLLA χ value nearly doubled to up to 75%. These results were used to develop a correlation model based on molecular weight decrease and were furthermore discussed in light of a detailed literature review. In summary, real-time in vitro studies could be adapted to accelerated protocols providing the same limiting conditions such as molecular weight and initial crystallinity are given.
Details
- Language :
- English
- ISSN :
- 01429418
- Volume :
- 107
- Issue :
- 107471-
- Database :
- Directory of Open Access Journals
- Journal :
- Polymer Testing
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.8416a49b8d94b18a37f79d8117774d5
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.polymertesting.2021.107471