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Palladium concave nanocrystals with high-index facets accelerate ascorbate oxidation in cancer treatment

Authors :
Yu Chong
Xing Dai
Ge Fang
Renfei Wu
Lin Zhao
Xiaochuan Ma
Xin Tian
Sangyun Lee
Chao Zhang
Chunying Chen
Zhifang Chai
Cuicui Ge
Ruhong Zhou
Source :
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Publication Year :
2018
Publisher :
Nature Portfolio, 2018.

Abstract

The therapeutic efficiency of ascorbate is limited by its slow autoxidation. Here, the authors show the application of concave-structured palladium nanocrystals for the treatment of colorectal cancer through the oxidation of ascorbate, enhancing the production of oxidative stresses specifically on cancer cells.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
9
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.845a165ecf944562a8374c43f5a51935
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-018-07257-z