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Effects of low-dose magnesium oxide on elevated serum magnesium levels and improved constipation in hemodialysis patients: a single-center retrospective study

Authors :
Takuya Yoshida
Taku Furukubo
Satoshi Izumi
Shigeichi Shoji
Tomoyuki Yamakawa
Source :
Renal Replacement Therapy, Vol 10, Iss 1, Pp 1-7 (2024)
Publication Year :
2024
Publisher :
BMC, 2024.

Abstract

Abstract Background The prevention of hypomagnesemia is critical for improving the life expectancy of patients undergoing hemodialysis (HD). The administration of magnesium oxide (MgO) increases serum Mg concentrations; however, dose adjustments must be done carefully owing to the risk of hypermagnesemia in patients undergoing HD. Additionally, the laxative effects of low-dose MgO on constipation in these patients has not been reported. Therefore, in the present study, we investigated the effects of treatment with low-dose MgO on serum Mg concentration changes and the improvement of defecation in patients undergoing HD. Methods The present study was a single-center retrospective observational study of 43 patients undergoing maintenance HD at Shirasagi Hospital. The patients’ clinical characteristics, including serum Mg concentration, were obtained from the hospital’s electronic medical records. In the group who received MgO for constipation, the effectiveness of MgO as a laxative was categorized as effective, ineffective, or unknown on the basis of electronic medical records related to defecation. Results Of the 43 patients included in the present study, 23 were prescribed supplemental Mg to prevent hypomagnesemia or maintain mild hypermagnesemia and 19 to prevent constipation. All patients received diasylate with an Mg concentration of 1.0 mEq/L. Additionally, 37 patients (86%) were treated with 330 mg/day MgO. The serum Mg concentrations before and 1, 2, and 3 months after the start of MgO were 2.3 ± 0.2, 2.8 ± 0.4, 2.8 ± 0.5, and 2.8 ± 0.4 mg/dL, respectively (P

Details

Language :
English
ISSN :
20591381
Volume :
10
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Renal Replacement Therapy
Publication Type :
Academic Journal
Accession number :
edsdoj.84646710e0074d58a1c2e7d4ce7bc1e8
Document Type :
article
Full Text :
https://doi.org/10.1186/s41100-024-00546-y