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The Role of Mitochondrial Metabolism, AMPK-SIRT Mediated Pathway, LncRNA and MicroRNA in Osteoarthritis

Authors :
Hao-Yu Liu
Chi-Fen Chang
Cheng-Chang Lu
Shun-Cheng Wu
Bin Huang
Tsung-Lin Cheng
Sung-Yen Lin
Cheng-Jung Ho
Mon-Juan Lee
Chung-Da Yang
Ying-Chun Wang
Jhong-You Li
Ping-Cheng Liu
Chun-Wang Wei
Lin Kang
Chung-Hwan Chen
Source :
Biomedicines, Vol 10, Iss 7, p 1477 (2022)
Publication Year :
2022
Publisher :
MDPI AG, 2022.

Abstract

Osteoarthritis (OA) is the most common joint disease characterized by degeneration of articular cartilage and causes severe joint pain, physical disability, and impaired quality of life. Recently, it was found that mitochondria not only act as a powerhouse of cells that provide energy for cellular metabolism, but are also involved in crucial pathways responsible for maintaining chondrocyte physiology. Therefore, a growing amount of evidence emphasizes that impairment of mitochondrial function is associated with OA pathogenesis; however, the exact mechanism is not well known. Moreover, the AMP-activated protein kinase (AMPK)–Sirtuin (SIRT) signaling pathway, long non-coding RNA (lncRNA), and microRNA (miRNA) are important for regulating the physiological and pathological processes of chondrocytes, indicating that these may be targets for OA treatment. In this review, we first focus on the importance of mitochondria metabolic dysregulation related to OA. Then, we show recent evidence on the AMPK-SIRT mediated pathway associated with OA pathogenesis and potential treatment options. Finally, we discuss current research into the effects of lncRNA and miRNA on OA progression or inhibition.

Details

Language :
English
ISSN :
22279059
Volume :
10
Issue :
7
Database :
Directory of Open Access Journals
Journal :
Biomedicines
Publication Type :
Academic Journal
Accession number :
edsdoj.84933996f20e4674b7ef79ca300e4d30
Document Type :
article
Full Text :
https://doi.org/10.3390/biomedicines10071477