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COMPUTER-ASSISTED STUDY OF THE REGULATION OF EUKARYOTIC GENE TRANSCRIPTION ON THE BASE OF DATA ON CHROMATIN SEQUENCING AND PRECIPITATION

Authors :
Yu. L. Orlov
Source :
Вавиловский журнал генетики и селекции, Vol 18, Iss 1, Pp 193-206 (2015)
Publication Year :
2015
Publisher :
Siberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and Breeders, 2015.

Abstract

The development of high-throughput sequencing technologies dramatically accelerated the accumulation of data on genome structure, distribution of gene regulatory regions in the genome and specific features of their interaction. Technologies associated with chromatin immunoprecipitation are reviewed: ChIP-PET, ChIP-seq, and ChIA-PET. Computer-assisted methods for the analysis of transcription factor binding sites (TFBSs) and regulatory region structures throughout the genome are described. The paper demonstrates approaches to the solution of tasks related to genomic data annotation and identification of TFBSs and regulatory regions.

Details

Language :
English, Russian
ISSN :
25003259
Volume :
18
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Вавиловский журнал генетики и селекции
Publication Type :
Academic Journal
Accession number :
edsdoj.84a6c87af36e4662ad4a68c1190fe32a
Document Type :
article