Sex Disparities and Neutralizing-Antibody Durability to SARS-CoV-2 Infection in Convalescent Individuals

Authors :: Alena J. Markmann
Natasa Giallourou
D. Ryan Bhowmik
Yixuan J. Hou
Aaron Lerner
David R. Martinez
Lakshmanane Premkumar
Heather Root
David van Duin
Sonia Napravnik
Stephen D. Graham
Quique Guerra
Rajendra Raut
Christos J. Petropoulos
Terri Wrin
Caleb Cornaby
John Schmitz
JoAnn Kuruc
Susan Weiss
Yara Park
Ralph Baric
Aravinda M. de Silva
David M. Margolis
Luther A. Bartelt
Source :: mSphere, Vol 6, Iss 4 (2021)
Publication Year :: 2021
Publisher :: American Society for Microbiology, 2021.
Abstract: In this study, we found that neutralizing antibody responses in COVID-19-convalescent individuals vary in magnitude but are durable and correlate well with receptor binding domain (RBD) Ig binding antibody levels compared to other SARS-CoV-2 antigen responses. In our cohort, higher neutralizing antibody titers are independently and significantly associated with male sex compared to female sex.

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