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Metabolomic analysis-identified 2-hydroxybutyric acid might be a key metabolite of severe preeclampsia

Authors :
Wang Fang
Xu Lili
Qi Mingming
Lai Huimin
Zeng Fanhua
Liang Furong
Wen Qing
Ma Xihua
Zhang Chan
Xie Kaili
Source :
Open Life Sciences, Vol 18, Iss 1, Pp 2817-21 (2023)
Publication Year :
2023
Publisher :
De Gruyter, 2023.

Abstract

This study set out to determine the key metabolite changes underlying the pathophysiology of severe preeclampsia (PE) using metabolic analysis. We collected sera from 10 patients with severe PE and from 10 healthy pregnant women of the same trimester and analyzed them using liquid chromatography mass spectrometry. A total of 3,138 differential metabolites were screened, resulting in the identification of 124 differential metabolites. Kyoto encyclopedia of genes and genomes pathway analysis revealed that they were mainly enriched in the following metabolic pathways: central carbon metabolism in cancer; protein digestion and absorption; aminoacyl-transfer RNA biosynthesis; mineral absorption; alanine, aspartate, and glutamate metabolism; and prostate cancer. After analysis of 124 differential metabolites, 2-hydroxybutyric acid was found to be the most critical differential metabolite, and its use allowed the differentiation of women with severe PE from healthy pregnant women. In summary, our analysis revealed that 2-hydroxybutyric acid is a potential key metabolite for distinguishing severe PE from healthy controls and is also a marker for the early diagnosis of severe PE, thus allowing early intervention.

Details

Language :
English
ISSN :
23915412
Volume :
18
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Open Life Sciences
Publication Type :
Academic Journal
Accession number :
edsdoj.84c9ffc26394403fa768888f45300209
Document Type :
article
Full Text :
https://doi.org/10.1515/biol-2022-0572