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Evaluation of oxidative stress, 3-Nitrotyrosine, and HMGB-1 levels in patients with wet type Age-Related Macular Degeneration

Authors :
Ramazan Zor Kürşad
Sarı İsmail
Yıldırım Biçer Gamze
Güntürk İnayet
Küçük Erkut
Erşan Serpil
Seydel Gönül Şeyda
Source :
Journal of Medical Biochemistry, Vol 41, Iss 3, Pp 275-281 (2022)
Publication Year :
2022
Publisher :
Society of Medical Biochemists of Serbia, Belgrade, 2022.

Abstract

Background: This study aims to compare serum HMGB-1, 3-nitrotyrosine (3-NT), TAS, TOS, and OSI levels in Wettype Age-Related Macular Degeneration (wAMD) patients and healthy controls to determine the correlation of these parameters with each other. Methods: Thirty patients with Wet-type Age-Related Macular Degeneration (wAMD) and 27 healthy adults, as controls were enrolled in the study. We determined the TAS and TOS levels in serum samples of both groups using commercial kits on a microplate reader. Serum HMGB-1 and 3-NT levels were measured with the enzyme-linked immunosorbent assay method. Results: HMGB-1 levels were significantly higher in the patient group (137.51 pg/mL, p=0.001), while there was no difference between the two groups in serum 3-NT levels (p = 0.428). A statistically significant difference found in the levels of TOS and OSI (p = 0.001 and p = 0.045, respectively) between the patients and controls, however, no significant difference was observed between the groups in terms of TAS levels (p = 0.228). Conclusions: Oxidative stress and HMGB-1 levels were increased in wAMD patients and enhanced oxidative stress may be associated with increased tissue necrosis and inflammation. Thus administration of antioxidant treatment in addition to routine therapy should be considered in wAMD.

Details

Language :
English
ISSN :
14528258 and 14528266
Volume :
41
Issue :
3
Database :
Directory of Open Access Journals
Journal :
Journal of Medical Biochemistry
Publication Type :
Academic Journal
Accession number :
edsdoj.84d2c72ff00f46d58da793581a2d42e5
Document Type :
article
Full Text :
https://doi.org/10.5937/jomb0-32189