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Avaliação prospectiva do perfil lipídico na artrite reumatóide Prospective evaluation of the lipid profile in rheumatoid arthritis

Avaliação prospectiva do perfil lipídico na artrite reumatóide Prospective evaluation of the lipid profile in rheumatoid arthritis

Authors :
Alessandra Barbosa Avelar
Ana Karla Guedes de Melo
Branca Dias Batista de Souza
Source :
Revista Brasileira de Reumatologia, Vol 48, Iss 4, Pp 213-217 (2008)
Publication Year :
2008
Publisher :
Sociedade Brasileira de Reumatologia, 2008.

Abstract

OBJETIVO: Avaliar a alteração do perfil lipídico na artrite reumatóide e sua associação com a atividade de doença. MÉTODOS: Estudo prospectivo de 21 pacientes, do sexo feminino, com artrite reumatóide, acompanhados durante um ano. Foram avaliados colesterol total, LDL-colesterol, HDL-colesterol, triglicérides, apolipoproteínas A e B, lipoproteína (a) e VHS, além de HAQ e índice de atividade de doença, por meio do DAS28. RESULTADOS: Após um ano, houve aumento significativo dos níveis de colesterol total (p = 0,019) em 66,6% das pacientes e de LDL-colesterol (p = 0,008) em 80,9% das pacientes. Quanto aos níveis de lipoproteína (a), houve redução significativa (p = 0,003) em 33,33% dos casos. Diminuição significativa ocorreu também no VHS, HAQ e DAS28. Porém, não houve associação entre a alteração do perfil lipídico e a atividade de doença. CONCLUSÃO: Embora tenha sido significativa a redução da atividade da doença (DAS28), houve piora do perfil lipídico.OBJECTIVE: To evaluate the lipid profile in rheumatoid arthritis and its association with the disease activity. METHODS: This was a prospective study with 21 female patients who had rheumatoid arthritis and whose progress was accompanied for 1 year. Total cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides, apolipoproteins A and B, lipoprotein (a), ESR, as well as HAQ and disease activity through DAS28, were evaluated. RESULTS: After 1 year, the total cholesterol level was increased in 66.6% of the patients (p=0.019) and the LDL-cholesterol level was also elevated in 80.9% of the patients (p=0.008). In contrast, the lipoprotein (a) level was reduced in 33.33% of the cases (p=0.003). A significant decrease also occurred in ESR, HAQ and DAS28. However, there was no association between the alteration of the lipid profile and the disease activity. CONCLUSION: Although the reduction in the disease activity (DAS28) was significant, the lipid profile worsened.

Details

Language :
English, Spanish; Castilian, Portuguese
ISSN :
04825004 and 18094570
Volume :
48
Issue :
4
Database :
Directory of Open Access Journals
Journal :
Revista Brasileira de Reumatologia
Publication Type :
Academic Journal
Accession number :
edsdoj.84e7572709e4bbfac8d55077ba47342
Document Type :
article
Full Text :
https://doi.org/10.1590/S0482-50042008000400004