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Sub-nanoliter metabolomics via mass spectrometry to characterize volume-limited samples

Authors :
Yafeng Li
Marcos Bouza
Changsheng Wu
Hengyu Guo
Danning Huang
Gilad Doron
Johnna S. Temenoff
Arlene A. Stecenko
Zhong Lin Wang
Facundo M. Fernández
Source :
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Publication Year :
2020
Publisher :
Nature Portfolio, 2020.

Abstract

The analysis of metabolites offers promises in biomarker discovery. Here the authors demonstrate the metabolomics analysis of sub-nanoliter samples using triboelectric nanogenerator inductive nanoelectrospray ionization, which they apply to exhaled breath condensate from cystic fibrosis patients and mesenchymal stromal cells.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
11
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.854b6b4ffa1f4bf9aea9c90c9d4b7608
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-020-19444-y