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A rare case of acute myeloid leukemia with t(12;19)(q13;q13)

Authors :
Alain Chebly
Fady Gh Haddad
Josiane Bassil
Tony Yammine
Rima Korban
Warde Semaan
Fady El Karak
Hampig Raphael Kourie
Chantal Farra
Source :
Leukemia Research Reports, Vol 14, Iss , Pp 100216- (2020)
Publication Year :
2020
Publisher :
Elsevier, 2020.

Abstract

Acute myeloid leukemia (AML) is characterized by chromosomal abnormalities affecting both prognosis and course of treatment. While most AML patients have well described chromosomal aberrations, around 10% present with rare chromosomal abnormalities.We herein, report a rare balanced translocation t(12;19)(q13;q13) in a 66-year old M5-AML patient identified by Conventional cytogenetic analysis and confirmed by SNP array. We suggest that t(12;19) as a sole chromosomal abnormality could be associated with a poor prognosis. Further studies are needed to understand the molecular basis of this translocation in AML.

Details

Language :
English
ISSN :
22130489
Volume :
14
Issue :
100216-
Database :
Directory of Open Access Journals
Journal :
Leukemia Research Reports
Publication Type :
Academic Journal
Accession number :
edsdoj.8574c7fabfed474d990f4cc2712c5ce6
Document Type :
article
Full Text :
https://doi.org/10.1016/j.lrr.2020.100216