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A rare case of acute myeloid leukemia with t(12;19)(q13;q13)
- Source :
- Leukemia Research Reports, Vol 14, Iss , Pp 100216- (2020)
- Publication Year :
- 2020
- Publisher :
- Elsevier, 2020.
-
Abstract
- Acute myeloid leukemia (AML) is characterized by chromosomal abnormalities affecting both prognosis and course of treatment. While most AML patients have well described chromosomal aberrations, around 10% present with rare chromosomal abnormalities.We herein, report a rare balanced translocation t(12;19)(q13;q13) in a 66-year old M5-AML patient identified by Conventional cytogenetic analysis and confirmed by SNP array. We suggest that t(12;19) as a sole chromosomal abnormality could be associated with a poor prognosis. Further studies are needed to understand the molecular basis of this translocation in AML.
Details
- Language :
- English
- ISSN :
- 22130489
- Volume :
- 14
- Issue :
- 100216-
- Database :
- Directory of Open Access Journals
- Journal :
- Leukemia Research Reports
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.8574c7fabfed474d990f4cc2712c5ce6
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.lrr.2020.100216