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Efficacy of chemotherapy combined with surgical resection for gastric cancer with synchronous ovarian metastasis: A propensity score matching analysis

Authors :
Jingquan Fang
Xingmao Huang
Xiangliu Chen
Qi Xu
Tengjiao Chai
Ling Huang
Han Chen
Hang Chen
Zeyao Ye
Yian Du
Pengfei Yu
Source :
Cancer Medicine, Vol 12, Iss 16, Pp 17126-17138 (2023)
Publication Year :
2023
Publisher :
Wiley, 2023.

Abstract

Abstract Background Ovarian metastasis from gastric cancer (GC) is characterized by aggressive biological behavior and poor outcome. Currently, there is no standard treatment mode for such patients. Thus, we evaluated the efficacy of conversion therapy in patients with synchronous ovarian metastasis from GC in this study. Methods About 219 GC patients with ovarian metastasis in 2011–2020 were enrolled. Two groups were established based on the different treatment: the conversion therapy group (chemotherapy combined with surgical resection, CS group) and the non‐conversion therapy group (NCS group). Propensity score matching (PSM) was used to analyze the efficacy of different treatment modes on the prognosis of these patients. Results Ninety‐two patients were included according to PSM results, with 46 patients each in CS and NCS groups. The median overall survival (OS) in the CS group was notably better than that in the NCS group (p

Details

Language :
English
ISSN :
20457634
Volume :
12
Issue :
16
Database :
Directory of Open Access Journals
Journal :
Cancer Medicine
Publication Type :
Academic Journal
Accession number :
edsdoj.85e3f21427448d392affeea8c35aef3
Document Type :
article
Full Text :
https://doi.org/10.1002/cam4.6362