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Mediator MED23 cooperates with RUNX2 to drive osteoblast differentiation and bone development
- Source :
- Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
- Publication Year :
- 2016
- Publisher :
- Nature Portfolio, 2016.
-
Abstract
- The transcription factor Runx2 regulates osteoblast differentiation of mesenchymal stem cells. In this manuscript, the authors, using a specific conditional knock-out mouse model and molecular studies, demonstrate that the mediator subunit MED23 binds to Runx2 and is essential for driving mesenchymal stem cells toward an osteoblast fate.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 7
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.85f1a579621d41f9903c5d1471ad188e
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/ncomms11149