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Genetic correlations of psychiatric traits with body composition and glycemic traits are sex- and age-dependent

Authors :
Christopher Hübel
Héléna A. Gaspar
Jonathan R. I. Coleman
Ken B. Hanscombe
Kirstin Purves
Inga Prokopenko
Mariaelisa Graff
Julius S. Ngwa
Tsegaselassie Workalemahu
ADHD Working Group of the Psychiatric Genomics Consortium
Meta-Analyses of Glucose and Insulin-related traits consortium (MAGIC)
Autism Working Group of the Psychiatric Genomics Consortium
Bipolar Disorder Working Group of the Psychiatric Genomics Consortium
Eating Disorders Working Group of the Psychiatric Genomics Consortium
Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium
OCD & Tourette Syndrome Working Group of the Psychiatric Genomics Consortium
PTSD Working Group of the Psychiatric Genomics Consortium
Schizophrenia Working Group of the Psychiatric Genomics Consortium
Sex Differences Cross Disorder Working Group of the Psychiatric Genomics Consortium
Substance Use Disorders Working Group of the Psychiatric Genomics Consortium
German Borderline Genomics Consortium
International Headache Genetics Consortium
Paul F. O’Reilly
Cynthia M. Bulik
Gerome Breen
Source :
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Publication Year :
2019
Publisher :
Nature Portfolio, 2019.

Abstract

Psychiatric disorders are often accompanied by alterations in BMI and body composition due to changes in eating behaviour and physical activity. Here, Hübel et al. study the genetic overlap between these traits and find that genetic correlations between psychiatric disorders and body composition are sex-specific and evident only in adulthood.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
10
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.863cf5db36a34aa2af52cbcbf3287303
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-019-13544-0