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G Protein-Coupled Estrogen Receptor 1 (GPER1) Mediates Aldosterone-Induced Endothelial Inflammation in a Mineralocorticoid Receptor-Independent Manner

Authors :
Ziwei Tang
Qifu Li
Qingfeng Cheng
Mei Mei
Ying Song
Zhipeng Du
Wenwen He
Jinbo Hu
Shumin Yang
Zhihong Wang
Source :
International Journal of Endocrinology, Vol 2021 (2021)
Publication Year :
2021
Publisher :
Wiley, 2021.

Abstract

Objective. It has been increasingly appreciated that G protein-coupled estrogen receptor 1 (GPER1) mediates both proinflammatory and anti-inflammatory response of estrogen. It is also involved in some rapid vascular effects of aldosterone in a mineralocorticoid receptor (MR) independent manner. However, whether GPER1 mediates aldosterone-induced inflammation response in endothelial cells and its relationship with MR are yet undetermined and therefore require further explanation. Method. Based on the hypothesis that GPER1 plays a role in the aldosterone-related vascular inflammation, the present study utilized a model of human umbilical vein endothelial cells transfected with MR siRNA and induced for inflammatory response with increasing concentration of aldosterone. Results. It was discovered that induction of aldosterone had no effect on the expression of GPER1 but promoted the expression of MR. Suppression of MR did not influence GPER1 expression, and GPER1 was capable of mediating part of aldosterone-induced endothelial inflammatory response. This effect may involve phosphoinositide 3-kinases (PI3K) pathway signaling. Conclusion. These findings not only demonstrated the role of GPER1 in aldosterone-induced vascular inflammation but also suggested an alternative for pharmaceutical treatment of hyperaldosteronism considering the unsatisfying effect on cardiovascular risks with MR antagonists.

Details

Language :
English
ISSN :
16878337 and 16878345
Volume :
2021
Database :
Directory of Open Access Journals
Journal :
International Journal of Endocrinology
Publication Type :
Academic Journal
Accession number :
edsdoj.863e804300be484cab8f8c85ec9d6ba5
Document Type :
article
Full Text :
https://doi.org/10.1155/2021/5575927