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Regulatory Effects of Maternal Intake of Microbial-Derived Antioxidants on Colonization of Microbiota in Breastmilk and That of Intestinal Microbiota in Offspring

Authors :
Dangjin Wu
Ran An
Di Wang
Luoxin Jiang
Liu Huang
Tenghui Lu
Weina Xu
Jianxiong Xu
Jing Zhang
Source :
Animals, Vol 14, Iss 17, p 2582 (2024)
Publication Year :
2024
Publisher :
MDPI AG, 2024.

Abstract

In this study, sixteen Sprague Dawley (SD) female rats and eight SD male rats were co-housed to mate. Pregnant SD female rats were fed with a control diet or an MA diet. Breast milk, maternal ileum, and intestinal samples of the offspring were collected at the day of birth and ten days afterwards. The results showed that the impact of MA was more obvious on the microbiota of mature milk (p = 0.066) than on that of colostrum. In addition, MA additive did not significantly affect maternal ileal microbiota, but affected offsprings’ colonic microbiota significantly ten days after birth (p = 0.035). From the day of giving birth to ten days afterwards, in addition to the increase in microbial richness and diversity, at genus level, the dominant bacteria of breastmilk changed from Pseudomonas veronii to Bacillus and Lactococcus. Different from breastmilk microbiota, ten days after giving birth, the maternal ileal microbiota and the offsprings’ intestinal microbiota were dominated by Lactobacillus. Instead of ileal microbiota, offsprings’ colonic microbiota is a key action site of maternal MA additive. Therefore, the current findings have significant implications for the development of maternal feed aimed at modulating the intestinal microbiota of offspring, ultimately leading to improved health outcomes for both mothers and their offspring.

Details

Language :
English
ISSN :
20762615
Volume :
14
Issue :
17
Database :
Directory of Open Access Journals
Journal :
Animals
Publication Type :
Academic Journal
Accession number :
edsdoj.864abe4fe274eb2be1037ad65422aa2
Document Type :
article
Full Text :
https://doi.org/10.3390/ani14172582