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Allelic Interference in Prion Replication Is Modulated by the Convertibility of the Interfering PrP C and Other Host-Specific Factors

Authors :
Juan Carlos Espinosa
Olivier Andreoletti
Alba Marín-Moreno
Severine Lugan
Patricia Aguilar-Calvo
Hervé Cassard
Patricia Lorenzo
Jean-Yves Douet
Ana Villa-Díaz
Naima Aron
Irene Prieto
Alvina Huor
Juan María Torres
Source :
mBio, Vol 12, Iss 2 (2021)
Publication Year :
2021
Publisher :
American Society for Microbiology, 2021.

Abstract

Prion propagation can be interfered with by the expression of a second prion protein in the host. In the present study, we investigated prion propagation in a host expressing two different prion protein genes.

Subjects

Subjects :
Microbiology
QR1-502

Details

Language :
English
ISSN :
21507511
Volume :
12
Issue :
2
Database :
Directory of Open Access Journals
Journal :
mBio
Publication Type :
Academic Journal
Accession number :
edsdoj.864be9f0adbd4cde9faed67640c7b37f
Document Type :
article
Full Text :
https://doi.org/10.1128/mBio.03508-20