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Genetic analysis of over half a million people characterises C-reactive protein loci

Authors :
Saredo Said
Raha Pazoki
Ville Karhunen
Urmo Võsa
Symen Ligthart
Barbara Bodinier
Fotios Koskeridis
Paul Welsh
Behrooz Z. Alizadeh
Daniel I. Chasman
Naveed Sattar
Marc Chadeau-Hyam
Evangelos Evangelou
Marjo-Riitta Jarvelin
Paul Elliott
Ioanna Tzoulaki
Abbas Dehghan
Source :
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Publication Year :
2022
Publisher :
Nature Portfolio, 2022.

Abstract

Inflammation is associated with a variety of diseases. Here, the authors identify 266 genetic loci associated with C-reactive protein levels, a marker of inflammation, in >500,000 Europeans, along with associated pathways, clinical outcomes and potential causal associations with disease.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
13
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.869522c3e7bb4df3b2e751de3d9aaab5
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-022-29650-5