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Histological phenotypic subtypes predict recurrence risk and response to adjuvant chemotherapy in patients with stage III colorectal cancer

Authors :
Antonia K Roseweir
James H Park
Sanne ten Hoorn
Arfon GMT Powell
Susan Aherne
Campbell SD Roxburgh
Donald C McMillan
Paul G Horgan
Elizabeth Ryan
Kieran Sheahan
Louis Vermeulen
James Paul
Andrea Harkin
Janet Graham
Owen Sansom
David N Church
Ian Tomlinson
Mark Saunders
Tim J Iveson
Joanne Edwards
Source :
The Journal of Pathology: Clinical Research, Vol 6, Iss 4, Pp 283-296 (2020)
Publication Year :
2020
Publisher :
Wiley, 2020.

Abstract

Abstract Histological ‘phenotypic subtypes’ that classify patients into four groups (immune, canonical, latent and stromal) have previously been demonstrated to stratify survival in a stage I–III colorectal cancer (CRC) pilot cohort. However, clinical utility has not yet been validated. Therefore, this study assessed prognostic value of these subtypes in additional patient cohorts along with associations with risk of recurrence and response to chemotherapy. Two independent stage I–III CRC patient cohorts (internal and external cohort) were utilised to investigate phenotypic subtypes. The primary endpoint was disease‐free survival (DFS) and the secondary endpoint was recurrence risk (RR). Stage II–III patients, from the SCOT adjuvant chemotherapy trial, were utilised to further validate prognostic value and for exploratory analysis assessing associations with adjuvant chemotherapy. In an 893‐patient internal cohort, phenotypic subtype independently associated with DFS (p = 0.025) and this was attenuated in stage III patients (p = 0.020). Phenotypic subtype also independently associated with RR (p

Details

Language :
English
ISSN :
20564538
Volume :
6
Issue :
4
Database :
Directory of Open Access Journals
Journal :
The Journal of Pathology: Clinical Research
Publication Type :
Academic Journal
Accession number :
edsdoj.86ccccce88334b4890153382c13043e0
Document Type :
article
Full Text :
https://doi.org/10.1002/cjp2.171