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Acid ceramidase of macrophages traps herpes simplex virus in multivesicular bodies and protects from severe disease
- Source :
- Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
- Publication Year :
- 2020
- Publisher :
- Nature Portfolio, 2020.
-
Abstract
- Macrophages are critical in limiting replication of herpes simplex virus type 1 (HSV-1). Here the authors show how acid ceramidase and its enzymatic product sphingosine enable multivesicular bodies to function as an anti-viral mechanism.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 11
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.87beeac86246829e4b47c4ed971f39
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-020-15072-8